The coordinated efficiency of fuze and warhead can be improved by integrated design of fuze and seeker. On the basis of the merits of the millimeter wave and infrared dual-mode compound detection, one design of Guidance Integrated Fuzing (GIF) is proposed integrating with wave-control fuze. The algorithm flow of the GIF is stated together with the corresponding meeting model. The impact factors of the optimum detonating angle are analyzed together with expression of detonating time-lapse. Finally, the estimated optimum detonating angle and detonating time-lapse respectively based on α-β(GH) and α-β-γ(GHK) filter are contrasted. The simulation results validate the efficiency and applicability of the mentioned two filters. The GH filter suits the missile-target encounter model with low speed and big encounter angle, while GHK filter suits the model with high speed and small encounter angle. The filtered data are precise and are able to provide reliable data for the predicted algorithm of the GIF.