Gypsum slag cement with low hydration heat and good chemical erosion resistance is a low carbon dioxide emission green cementitious material. To clearify to the effect of raw materials on the resistance of gypsum slag cement concrete to sulfate attack, the strength development and sodium sulfate corrosion resistance of gypsum slag cement concrete prepared with different chemical composition and active granulated blast furnace slag (GBFS) were studied. The results show that increasing the content of Al2O3 in GBFS effectively improves the early 3 d strength of gypsum slag cement concrete. The strength of gypsum slag cement concrete increases first and then decreases in sodium sulfate environment, showing strength softening disadvantage. Increasing the amount of cement and reducing the water to cement ratio effectively improves the sodium sulfate corrosion resistance of gypsum slag cement concrete prepared with low active GBFS, but it is not conducive to the sodium sulfate corrosion resistance of gypsum slag cement concrete prepared with high active GBFS. The research provides experimental data supporting for the preparation of gypsum slag cement concrete with low active GBFS and predicting for its life.