Liu Ruonan, Li Tingting, Zhou Qiumei, Gu Yueqing. Application of Gold-Nanoparticle-Based Fluorescent Molecular Beacons in BRCA1 mRNA Detection[J]. Chinese Journal of Lasers, 2018, 45(2): 207021
- Chinese Journal of Lasers
- Vol. 45, Issue 2, 207021 (2018)
Fig. 1. Ultraviolet-visible absorption spectra of gold nanoparticles and BRCA1 gold-nanoparticle-based molecular beacons
Fig. 2. TEM images. (a) Gold nanoparticles; (b) BRCA1 gold-nanoparticle-based molecular beacon
Fig. 3. Hybridization of BRCA1 gold-nanoparticle-based molecular beacon and complementary DNA
Fig. 4. Relationship between fluorescence intensity of BRCA1 gold-nanoparticle-based molecular beacon and target-sequence concentration
Fig. 5. Stability of BRCA1 gold-nanoparticle-based molecular beacon
Fig. 6. Fluorescence intensities of BRCA1 gold-nanoparticle- based molecular beacons under different pH
Fig. 7. Cytotoxicity of BRCA1 gold-nanoparticle- based molecular beacon
Fig. 8. Confocal microscopy imagings of BRCA1 gold-nanoparticle-based molecular beacon in BGC823 and BGC823/DDP. (a) BGC823, bright field image; (b) BGC823, fluorescence image; (c) BGC823/DDP, bright field image; (d) BGC823/DDP, fluorescence image
Fig. 9. Fluorescence intensities of BRCA1 gold-nanoparticle-based molecular beacon in BGC823 and BGC823/DDP
Fig. 10. Relative expression of BRCA1 mRNA in BGC823 and BGC823/DDP
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