A possibility to measure glucose concentration using a Michelson partial coherent interferometer (LCI) is presented. For three different glucose concentrations, 0.18 mg/mL (hypoglycemia), 0.95mg/mL (normal level) and 3.36 mg/mL (hyperglycemia) the second-order dispersion is investigated over the wavelength range 0.5 μm to 0.85 μm, and the investigation shows that different concentrations are associated with different second-order dispersions. The second-order dispersions for wavelengths from 0.55 μm to 0.8 μm are determined by Fourier analysis of the interferogram. This approach can be applied to measure the second-order dispersion for distinguishing the different glucose concentrations. It can be expected as a potentially noninvasive method to measure glucose concentration in human body.