For using the time and space frequency resources in imaging transmission fully, a new hybrid optical code division multiaddress (CDMA) coding scheme is proposed, which is based on imaging transmission with two-dimensional optical orthogonal pattern code and time frequency spread spectrum. Then the authors analyze the multiplex access interference noise and calculate the probability density function of interference noise in interfering optical orthogonal signature codes. The bit-error rate caused by the multiplex access interference noise is derived and plotted as a function of receiver threshold, number of users, code length and code weight product. Compared respectively with time spreading code and spatial spreading code optical CDMA, the authors' scheme has a lower bit-error rate and releases the requisition of relative devices such as the number of code chips in time domain and the pixels in space domain. Finally a design scheme of encoder-decoder is presented.