Specific Identification of Breast Tumors Based on Laser-Induced Autofluorescence Spectroscopy

Jianfeng Yan; Jiayuan Li; Xing Zhang; Jun Tan; Jinyu Fu; Caifeng Ou; Chengyun Zhang; Yunfeng Luo; Zhifeng Chen; Pusheng Zhang

doi:10.3788/CJL230982

Journals >Chinese Journal of Lasers >Volume 50 >Issue 21 >Page 2107201 > Article

Chinese Journal of Lasers
Vol. 50, Issue 21, 2107201 (2023)

Specific Identification of Breast Tumors Based on Laser-Induced Autofluorescence Spectroscopy

Jianfeng Yan¹, Jiayuan Li¹, Xing Zhang², Jun Tan¹, Jinyu Fu¹, Caifeng Ou³, Chengyun Zhang¹, Yunfeng Luo², Zhifeng Chen^1、*, and Pusheng Zhang^2、**

Author Affiliations

¹School of Physics and Materials Science, Guangzhou University, Guangzhou 510006, Guangdong, China

²Department of Breast Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, Guangdong, China

³Department of Breast Care Surgery, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, Guangdong, China

show less

DOI: 10.3788/CJL230982 Cite this Article Set citation alerts

Jianfeng Yan, Jiayuan Li, Xing Zhang, Jun Tan, Jinyu Fu, Caifeng Ou, Chengyun Zhang, Yunfeng Luo, Zhifeng Chen, Pusheng Zhang. Specific Identification of Breast Tumors Based on Laser-Induced Autofluorescence Spectroscopy[J]. Chinese Journal of Lasers, 2023, 50(21): 2107201 Copy Citation Text

show less

Fig. 1. Experimental system for laser-induced steady fluorescence spectroscopy

Download full size

Laser-induced steady autofluorescence spectra of normal breast gland tissues and breast malignant tumor tissues. (a) Normal breast gland tissues; (b) breast malignant tumor tissues

Fig. 2. Laser-induced steady autofluorescence spectra of normal breast gland tissues and breast malignant tumor tissues. (a) Normal breast gland tissues; (b) breast malignant tumor tissues

Download full size

Fig. 3. Identification effect of three fluorescence ratio methods on normal breast glands and breast malignant tumors. (a) I₄₃₀/I₄₆₅ fluorescence ratio method; (b) I₄₃₀/I₄₀₀ fluorescence ratio method; (c) 2I₄₃₀/(I₄₀₀+I₄₆₅) fluorescence ratio method

Download full size

Fig. 4. Gaussian decomposed fittings of normal breast glands and breast malignant tumors spectra. (a) Normal breast glands spectra; (b) breast malignant tumors spectra

Download full size

Tissue	Fitting results
Tissue	Peak 1	Peak 2	Peak 3	Peak 4
Fluorophore	Collagen+elastin		NADH	Flavin adenine
Gland	8.8%±1.2% 389 nm±0.46 nm	18.4%±3.3% 416 nm±1.34 nm	31.4%±8.4% 465 nm±3.01 nm	41.3%±7.9% 532 nm±13.43 nm
Tumor	4.0%±0.6% 384 nm±0.31 nm	11.5%±0.9% 401 nm±1.23 nm	46.8%±6.8% 459 nm±1.20 nm	37.6%±8.0% 537 nm±18.92 nm

Table 1. Spectral fitting results and corresponding fluorophores

Download Citation

Set citation alerts for the article

Tools

Set citation alerts for the article

Save the article for my favorites

Paper Information