According to the requirement of detector in high energy physics and nuclear physics national scientific equipment, the large-area micro-channel plate photomultiplier(MCP-PMT) different from dynode PMT was researched. The large-area MCP-PMT had low-background glass and microchannel plate multiplier. Using Sb-K-Cs as photocathode, MCP-PMT enjoyed very high quantum efficiency at 350-450 nm. With double MCPs as electron amplifier, the gain could reach 107. The detection efficiency and single photon detection of large-area PMT was improved. Compared with conventional dynode PMT, this MCP-PMT is a completely new design in structure and has better ratio of spectrum peak to valley, high gain, better anode uniformity, fast response time in single photoelectron detection.