• Chinese Optics Letters
  • Vol. 15, Issue 9, 090007 (2017)
Roshan Dsouza1、2, Hrebesh Subhash3, Kai Neuhaus1, Paul M. McNamara1、2, Josh Hogan4, Carol Wilson4, and Martin J. Leahy1、5、*
Author Affiliations
  • 1Tissue Optics and Microcirculation Imaging Group, School of Physics, National University of Ireland, Galway H91 CF50, Ireland
  • 2Compact Imaging Ireland Ltd., Galway H91 CF50, Ireland
  • 3Colgate-Palmolive Global Technology Centre, Piscataway NJ 08855, USA
  • 4Compact Imaging, Inc., Mountain View 94043, USA
  • 5Royal College of Surgeons (RCSI), Dublin, Ireland
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    DOI: 10.3788/COL201715.090007 Cite this Article Set citation alerts
    Roshan Dsouza, Hrebesh Subhash, Kai Neuhaus, Paul M. McNamara, Josh Hogan, Carol Wilson, Martin J. Leahy. Feasibility study of phase-sensitive imaging based on multiple reference optical coherence tomography[J]. Chinese Optics Letters, 2017, 15(9): 090007 Copy Citation Text show less

    Abstract

    Multiple reference optical coherence tomography (MR-OCT) is a recently developed, low-cost and compact time-domain OCT solution for primary care and consumer level applications. A combination of a voice coil actuator and a partial mirror (PM) extends the scan range for imaging depths of approximately 1 mm in biological samples. Our previous research on MR-OCT is based only on intensity information obtained from the depth-resolved interference signal. In this Letter, we extract the phase information from the MR-OCT signal and, hence, provide an additional contrast modality. The phase sensitivity of the system is measured to be approximately 0.2 and 1.5 rad for the first and twelfth orders of reflection when using a mirror as the sample. This Letter describes first results of phase-sensitive data measured on a phantom obtained with MR-OCT. Data from a chick embryo chorioallantoic membrane (CAM) is used to demonstrate the feasibility of MR-OCT for in vivo phase-sensitive imaging.
    φ=tan1[Im(Γ˜i(t))Re(Γ˜i(t))].(1)

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    Δφm=φm·(j+1)φm·j¯|j=1j=8.(2)

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    D(m)=s2+d(m1)+m·s2,(3)

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    Vmax=±λ04·Δt,Vmin=±λ04·Δt·Δφσ·mπ,(4)

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    V=Δφ·λ04πnΔt·cos(θ)(5)

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    Roshan Dsouza, Hrebesh Subhash, Kai Neuhaus, Paul M. McNamara, Josh Hogan, Carol Wilson, Martin J. Leahy. Feasibility study of phase-sensitive imaging based on multiple reference optical coherence tomography[J]. Chinese Optics Letters, 2017, 15(9): 090007
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