Tapered microstructure fibers with different taper lengths and waist diameters are pumped with femtosecond laser for supercontinuum generation. With “fast and cold tapered method”, home made microstructure fiber with air-hole pitch Λ=6.53 μm and normalized air-hole diameter d/Λ=0.79 were tapered to 6, 8, 10 mm taper length while keeping d/Λ unchanged. Numerical simulations show that the zero dispersion wavelength shifts to blue when the taper waist shrinks. The zero dispersion wavelengths for untapered and 6, 8, 10 mm length tapered fiber were 1 029, 885, 806, and 637 nm, respectively. In the experiment, 120 fs pulses centered at 810 nm, which is generated by mode-locked Ti:sapphire laser at a repetition rate of 76 MHz, is coupled into the tapered microstructure fiber. With the tapered length of 6 mm, the center wavelength of the pump light locates in the normal dispersion region of the fiber and near the zero dispersion wavelength of the tapered waist. The main factors causes spectra broaden are intrapulse Raman scattering and cascaded four-wave mixing. When the pump power reaches 450 mW, continuous spectra with -5 dB flatness are generated at 390~461 and 1 134~1 512 nm. With 500 mW pump power, supercontinuum spans from 366 to 2 450 nm, which has already covered ultraviolet, visible, near-infrared and mid-infrared. This broadband spectrum almost reaches the red and blue edges of the microstructure fiber’s transmission bandwidth. With 8mm tapered length and 450 mW pump power, the blue edge of the continuous spectrum shifts down to 366 nm as a result of group velocity match and group acceleration mismatch, a 9 nm deeper blue shift compared to results from 6mm tapered length. With the tapered length of 10 mm, because the zero dispersion wavelength of the waist also moves to visible region, phase matching condition can still be satisfied in that region. Due to the effect of cascaded four-wave mixing, the frequency up conversion is realized in visible region. When pump power reaches 500mW, up conversion frequency lies in 30 nm band from 382 to 412 nm, the conversion efficiency is up to 27.7%.