Fluorescence analysis and time-resolved fluorescence immunoassay (TRFIA) are often used in screening of new born babies′ desease, while there is no domestic instrument having a collection of two measurements. A multi-function time-resolved instrument is developed to integrate two measurements, which is a lens-optical fiber combined instrument. According to the US. Committee for Clinical Laboratory Standards (NCCLS) documents and related literatures, the instrument is tested. It is compared with THERMO Varioskan Flash and PekinElmer Wallac 1420, which are used widely by major hospitals in China. The results show that the specification of the instrument are in line with requirements, and it could be put into practical production.