Borosilicate glass was treated as basic glass substrate, and the influence of alkaline earth metal oxide content on the crystallization behavior of waste glass containing 16% (mass fraction) simulated high level liquid wastes was investigated, in order to suppress the crystallization tendency by controlling the content of alkaline earth metal oxide under the premise of ensuring the performance requirements. The results show that, when the content of alkaline earth metal oxide is 7%~19% (mass fraction), the maximum crystallization temperature and the crystallinity of the waste glass gradually decrease with the decrease of alkaline earth metal oxide (CaO+MgO+BaO) content. The increase of the degree of polymerization of the glass network is beneficial to improving the anticrystallization performance of the waste glass. However, when the alkaline earth metal oxide content is lower than 11% (mass fraction), the solubility of sulfate has a significant decrease. Based on the requirement of inclusion of 0.7% (mass fraction) SO3, the appropriate composition of alkaline earth metal oxide content is above 11% (mass fraction).