In the real-time atmospheric data collecting system, atmospheric data can be collected with multi-serial communication at the same time. Based on VC++6.0, how to use MSComm control to realize multi-serial communication is introduced. The procedure is depicted containing sending pretreatment datum from serial device RS232 to PC, and bringing the collection datum display, storage and transmission to come true. The scheme is simple and practical, and it is successfully used in the multi-serial interface real-time acquisition and processing system. The communication portion adopts UDP/IP.