The detection mission of gravitational waves in space is that the accuracy of the long-baseline intersatellite laser interferometry on the million-kilometer order needs to reach the order of 8 pm/ Hz . Among all noise sources that affect the interferometry accuracy, tilt-to-length (TTL) coupling noise is the second largest source of noise after shot noise. This paper focuses on studying the contribution of TTL coupling noise of the telescope system in the intersatellite scientific interferometer. By referring to the laser interferometer space antenna (LISA)’s noise budget, TTL coupling noise is required to be within ±25 μm/rad (±300 μrad). Therefore, this paper focuses on studying both the mechanism of TTL coupling noise due to the noise sources of the telescope and the method of suppressing the TTL noise, which can lay a foundation for noise distribution and the development of engineering prototypes in subsequent tasks.