A novel optical fiber transmission system for low bending loss, large mode area and single-mode operation is proposed. The system is composed of a multi-mode photonic crystal fiber (PCF) and two single-mode PCFs. The single-mode PCFs are connected to each side of the multi-mode PCF. Numerical simulation on the mode area, the bending loss, the splicing loss and other aspects of the transmission system indicates that the system can effectively suppress the transmission of higher order modes. In addition, at the operating wavelength of 1064 nm, the multi-mode PCF has a large mode area of 1593 μm2 when it is kept straight, and exhibits a low bending loss even at a small bending radius of 10 cm. The splicing loss between the multi-mode and single-mode PCFs can be as low as 0.085 dB for the optimized PCF configurations.