Target characteristics is not obvious for infrared opto-electronic systems due to the complex scene under the conditions of mobile carriers such as aircrafts, as a result in this situation weak moving target detection is a big difficulty in the field of automatic target detection. A new method was proposed for this problem which was independent of image content. Through the combination of aircraft′s inertial integrated navigation information, the geographical location of the pixel points in the image was calculated and then the corresponding points between the consecutive frames were obtained. So the movement of the background was acquired and the motion compensation was conducted, and the target was highlighted. Finally, the target was confirmed by backward verification using target motion information. The experiments show that the new algorithm can obtain a better detection results.