Thin wall samples from Ti2AlNb-based alloy are deposited on TA15 titanium alloy plate by laser melting deposition of coaxially fed Ti-22Al-25Nb metallic powders. The microstructure, phase constitution for as-deposited and heat treated materials are investigated. The tensile properties along longitude direction at room temperature and 750 ℃ high temperature are tested for materials after heat treatment. The results show that laser direct deposited Ti2AlNb-based alloy is full dense. Both as-deposited and heat treated materials are composed of B2, α2 and O phases. For the deposited Ti2AlNb-based alloy after heat treatment, the tensile strength at room temperature and 750 ℃ are 1012 MPa and 702 MPa, with elongations of 1.8% and 2.2%, respectively.