The brand-new micro-channel heat sinks are designed using plug-in fins and simulated. The impact factors, namely coolant, flow rate and heat sink geometry, are considered in the study of the flow and heat transfer performance of heat sink. The optimal operating condition is obtained by the method of orthogonal simulation by considering the notability of each factor. It is found that the orthogonal simulation method can save cost both in time and money. The orthogonal simulation method performs well in the design of channel sink.