To improve the wear-resisting property of TC4,an experiment of laser cladding (Ti+ Al/Ni)/(Cr2O3+CeO2) on titanium alloy by pulsed Nd:YAG had been carried out. The effects of processing parameters on the cladding layer height, dilution rate and penetration into the substrate had been examined. Microstructure of the layer was investigated, and microhardness was measured. It was found that both the clad height and penetration into the substrate increased with the increasing pulse energy. The dilution rate reached the lowest value (3.95%) at the incident energy of 20 J/pulse, pulse width of 8ms,the scanning speed of 1.1mm/s and pulse frequency of 5 Hz. The microstructures of the cladding layer were dispersive undissolved Cr2O3 particles and orbed liquid-precipitated Cr2O3 distributed in the matrix consisting of fir-tree crystals and eutectics. And the ceramic hardening particles of TiAl was existed. The hardness of the cladding layer increased obviously, the maximum was 1150 Hv,2～3 times of the substrate. A white narrow metallurgical bonding zone was formatted at interface between the clad and the substrate, about 10～20 μm. The cladding layer was continuous, homogeneous, poreless and crackless by optimizing the technical parameters.