Based on the technology maturity, four typical nuclear fuel cycle options, namely, OTC, TTC, FRC and HRC, were selected for analysis. The sustainability of different fuel cycle options was studied using the balanced mass flow model, and the fuel cost and spent fuel disposal cost of different options were evaluated based on levelized cost of electricity calculation method. The results show that closed fuel cycle can greatly reduce the production of nuclear waste. And the FRC option with fuel self-supporting as well as the HRC option can use depleted uranium without consuming natural uranium. Besides, the HRC option is the most economical while the TTC option is the worst, considering only fuel cost and spent fuel disposal cost.