The image non-uniformity is related to many factors such as lens, detector assembly, spatial stray light, etc. The single correction method can not distinguish the error source effectively. In view of the on orbit working mode of polarization imager based on integral time adjustment, the non-uniformity correction method of detector based on multi parameters is studied. Through the comprehensive test equipment of CCD detector, the datas of sensitive factors such as temperature, dark current, exposure time and specrtal response are obtained. After a seris of preprocessing of the image including removal of darkness signal, removal of smearing effect and temperature conpenstion, the low-frequency unbalanced response difference of the image surface is eliminated, and the high-frequency difference is effectively suppressed. The experimental results show that the photo response non-uniformity of 95% full well single frame data is reduced from 1.141% to 0.513%. After correction, the data noise is shown as shot noise. After correction, the detectorhas good dynamic range adjustment ability and linearity. The non-uniformity correction method based on multi parameters is used to provide data support for calibration correction and on orbit fast calculation of the instrument, and provide effective reference for the following polarization remote sensing instruments.