Based on ground-based Fourier transform infrared remote sensing and in-situ surface measurement, the variation of atmospheric CH₄ and CO₂ concentrations in Hefei City, China, from January 2016 to December 2017 were investigated. The observation results show that there were obvious seasonal variations in CO₂ and CH₄ over Hefei. CO₂ showed a minimum value in August 2016, and then gradually increased over time, reaching the maximum in April 2017. After that, it declined gradually, reaching another minimum value in early September 2017. In contrast, CH₄ showed high level in summer and early autumn, and low concentrations in winter and early spring. In 2016, the seasonal amplitudes of the monthly mean concentrations of XCO₂ and XCH₄ measured by ground-based remote sensing were 5.96 $\times {\mathrm{10}}^{-\mathrm{6}}$ and 0.047 $\times {\mathrm{10}}^{-\mathrm{6}}$ respectively, while those of CO₂ and CH₄ measured in-situ were 31.46 $\times {\mathrm{10}}^{-\mathrm{6}}$ and 0.26 $\times {\mathrm{10}}^{-\mathrm{6}}$ respectively, about 5 times of the corresponding values measured by ground-based remote sensing. The correlation between atmospheric CO₂ and CO, as well as CH₄ and CO₂, at Hefei Station was analyzed. It is shown that the correlation coefficient R between XCO₂ and XCO measured by ground-based remote sensing in autumn is 0.75, and the ratio of XCO₂ and XCO is 79.5. The strong correlation between XCO₂ and XCO indicates that most of CO₂ and CO in Hefei area in autumn originate from the same sources. On the other hand, the correlation coefficient R of CO₂ and CO, CH₄ and CO₂ measured by in-situ surface measurement in winter is 0.80, the ratio of CO₂ and CO is 52.2, and the ratio of CH₄ and CO₂ is 0.0036. The strong correlations between gases indicate that anthropogenic sources are main sources of CO₂ at Hefei Station in winter, and CH₄ and CO₂ partially originate from biomass burning.