In the present work,computer simulation was performed on a model chemical system where two solutes(denoted as P and Q,respectively) are dissolved in the same solution.Under intermolecular interaction between P and Q,part of P undergoes subtle structural variation and converts into U while part of Q converts into V.The strength of intermolecular interaction can be characterized by the corresponding equilibrium constant K.Our preliminary studies indicate that the S/N ratio of cross peak increases considerably as n increases.Moreover,the S/N ratio of the cross peak from the asynchronous spectra can be improved significantly when the suitable concentrations of P and Q are adopted.This work is helpful for a selection of suitable concentration sequence to maximize S/N ratio of cross peaks in the 2D asynchronous spectra generated by using the DAOSD approach proposed in our previous study so that weak intermolecular interaction can be probed.