The process of selective laser melting (SLM) direct manufacturing based on CoCrMo alloy is studied to explore the optimized process of CoCrMo personalized medical products that are in increasing demand. SLM equipment Di-Metal100 self-developed by South China University of Technology is used. When the CoCrMo alloy satisfying the requirement of ASTM F75 is manufactured by SLM, three critical process parameters including laser power, scanning speed and scanning space are carried out process validation and analysis so that the process parameters with high relative density is obtained and through which the mechanical performance of parts manufactured is tested. The result shows that with the laser power of 170 W, scanning space of 0.08 mm and scanning speed of 500 mm/s, CoCrMo alloy samples manufactured directly by SLM with 99.02% relative density are obtained. Their tensile strength, yield strength σ0.2 and Rockwell hardness are all higher than the casting standard of ASTM F75 and their elongations are slightly lower. Through the process optimization of SLM direct manufacturing based on CoCrMo alloy, CoCrMo alloy personalized medical products meeting the target of medical product in performance can be manufactured, which provides important reference for personalized SLM direct manufacturing based on CoCrMo alloy.