Herein, this article was focused on the synthesis and discussed the spectroscopic characterizations of four new scandium(Ⅲ) sulfa-drug complexes. The nomenclature and symbols of these drugs were sulfadimidine (sulp-1), sulfanilamide (sulp-2), sulfamethoxazole (sulp-3) and sulfadiazine (sulp-4). The microanalytical and spectroscopic analyses which utilized in this study were micro-analyses, magnetic, FT-IR, UV-Vis techniques. The mid infrared spectra deduced that the four sulfa-drug chelates acts as a bidentate chelates with scandium(Ⅲ) ion via two nitrogen atoms of —NH2-Ar and —NH-SO2 groups. Also, the FTIR spectra of Sc3+ complexes referred to the existed of new medium weak bands in the range of 500～400 cm-1 due to stretching vibration bands of ν(M—N). The elemental analysis technique confirmed the 1∶2 stoichiometry between Sc3+ ions and sulp ligand with molecular formula ［Sc(sulp)2(Cl)2］·Cl. At room temperature, the results of magnetic measurements for the Sc(Ⅲ) complexes indicated that all of the synthesized complexes have a diamagnetic character with octahedral configuration. The electronic spectra of the free sulfa-drug ligands shows band at 275 and 310 nm which are intraligand charge transfer band. The electronic sbsorption spectra of the Sc3+ complexes were recorded using DMSO solvent. The spectra of complexes display bands within 275～388 nm, which attributed to π—π*, n—π* and charge-transfer M-LCT electronic transitions, which strongly favors the octahedral geometry around Sc(Ⅲ) metal ions. 1HNMR spectra of complexes referred to the downfield proton shifts of the —NH2 and NHSO2 groups, which supported the place of coordination. The half maximal inhibitory concentration (IC50) of the ScⅢ complexes was assessed against the human hepato cellular carcinoma (HepG-2) tumor cell line.