In order to investigate the influence mechanism of various industrial solid waste powders on the mechanical properties and durability of high-performance self-compacting concrete (HPSCC)an experimental investigation was conducted on the concrete with various mass fraction of fly ashfurnace slaglime powdercoal gangue powder and marble powder. The slump flowT50 flow timeL-box and V-funnel flow time were experimentally measured to evaluate the workability of HPSCC. The concrete mechanical properties were evaluated by measuring ultrasonic pulse velocity and compressive strength. In additionthe power consumption and water penetration depth were tested to characterize its durability. The results show that fly ashfurnace slaglime powdercoal gangue powder and marble powder can be used to prepare HPSCC with excellent workability and durability. The allowable mass fraction of fly ash and furnace slag powder is 35% and 60%respectively. Whilethe allowable mass fraction for coal gangue powderlime powder and marble powder is 30%respectively. The addition of fly ash significantly improves the concrete workabilitywith a maximum slump flow of 750 mm. Except for lime powderthe increase of other industrial solid waste powders leads to a better concrete anti-chloride ion permeability. Howeverthe increase of industrial solid waste powders can reduce the impermeability and compressive strength of concrete. The concrete mixed with 30% lime powder shows the largest decrease in compressive strengthwith a reduction of 20.8%.