In order to avoid the effect of photon defect on the imaging during X-ray generation, an imaging integral filter based on quantum enhancement was proposed in this paper to effectively reduce the sensitivity of X-ray detection system for quantum noise. Firstly, the coupling constraint at the end of the image intensifier was analyzed by discussing the X-ray imaging mechanism. The effects of quantum thermal noise and defects on spectrum transfer were studied from the micro perspective. Then the effectiveness of the new integral filter method was verified from the view of the integral effect of fundamental space frequency transfer characteristics in Fourier spectrum. Finally, the superiority and real-time performance of the quantum enhancement filter method were verified by the comparison filter testing.