In response to the UN goal of sustainable development and poverty eradication in 2030, the Chinese government put forward and implemented the national strategy of targeted poverty alleviation in 2014. Scholars have carried out much research from the perspective of poverty factors, poverty types and spatial poverty traps, etc., but the empirical research and policy analysis of specific poverty alleviation measures have not been given enough attention. Based on the data samples of 6378 villages in China, this study analyzed the implementation and progress of the village based assistance measures in the targeted poverty alleviation work, identified the main factors affecting the effectiveness of the village based assistance with the measurement method, and measured the poverty reduction effect of the assistance work. The results show that the first secretary of the village assistance is mainly composed of male cadres sent by county-level units, with an average age of 42 years and education background mainly from universities. During the implementation of the work, the principle of adopting different village strategies according to the needs has been maintained. The specific assistance measures include the development of industry, the cultivation of labor force, the transformation of houses, and the hardening of roads. There are obvious regional differences in the implementation and achievements of these measures. Generally speaking, the poverty alleviation work in the western region is better than that in the central region. The empirical results of the econometric model show that the effect of the assistance work in the village is affected by multiple factors, and the personal characteristics of the first secretary, such as age, education background and work unit, has significant impact on poverty reduction. At the same time, the poverty alleviation measures taken by the task force have a far-reaching significance for improving the public infrastructure in poor areas. The research results will be helpful to provide theoretical basis and decision support for the smooth promotion of the effective connection between targeted poverty alleviation and rural revitalization in China.