To improve the signal-to-noise ratio and imaging quality of aerospace TDICCD remote sensing cameras, in-depth research was conducted on the crosstalk between the imaging spectral bands of TDICCD remote sensing cameras. In the design process of high-density TDICCD imaging circuits, owing to the limited space, dense layout, and wiring of PCB circuit boards, the isolation between signals is unsatisfactory, thus resulting in crosstalk between the spectral bands of the signals. This type of crosstalk significantly affects the acquisition of effective signals in various spectral bands. Under different operating frequencies of each spectral band, crosstalk stripes are generated in the image. This article first introduces the composition of an imaging system based on signal processing and describes two types of crosstalk phenomena. Subsequently, the causes of crosstalk and its boundary conditions are analyzed, and a solution for suppressing imaging crosstalk is provided. Finally, imaging and signal-to-noise ratio testing are conducted on an improved TDICCD imaging system. The experimental results show that the measures adopted effectively removed the crosstalk stripe between the TDICCD imaging spectral bands as well as significantly improved the camera signal-to-noise ratio. Under a camera radiance of 133.729 W/(m²×Sr), the camera signal-to-noise ratio increased by 6.92 dB to 47.83 dB, thus satisfying the demands of practical engineering.