Sapphires (Al₂O₃) is an important ceramic material with extensive applications in high-pressure technology and geoscience. For instance, it is often used as a window material in shock-wave experiments. Consequently, understanding the behavior of its transparency change under shock compression is crucial for correctly interpreting the experimental data. Sapphire has excellent transparency at ambient conditions, but its transparency is reduced under shock loading. This shock-induced optical extinction phenomenon in Al₂O₃ has been studied experimentally and theoretically a lot at present, but the knowledge on the crystal-orientation effects of the extinction is still insufficient. the experimental investigations at low-pressure region (within 86 GPa) have indicated that the shock-induced extinction in Al₂O₃ is related to its crystal orientation, but it is not clear whether the correlation also exists at high-pressure region (~131–255 GPa). Here, to investigate this question, we have performed first principles calculations of the optical absorption properties of a-, c-, d-, r-, n-, s-, g- and m-oriented Al₂O₃ crystals without and with $V_{\rm O}^{ + 2}$ (the +2 charged O vacancy) defects at the pressure range of 131–255 GPa. It is found that: 1) there are obvious crystal-orientation effects of the extinction in shocked Al₂O₃ at high-pressure region, and they strengthen with increasing pressure; 2) shock-induced $V_{\rm O}^{ + 2}$ defects could play an important role in determining these crystal-orientation effects, but the influences of pressure and temperature factors on them are relatively weak. A further analysis shows that, at the wavelength range adopted in shock experiments, the extinction of a-orientation is the weakest (the best transparency), the extinction of c-orientation is the strongest (the worst transparency), and the extinction of s-orientation is between them; at the same time, the extinction of m-orientation is similar to that of a-orientation, the extinction of r-, n- and d-orientations is close to that of c-orientation, and the extinction of g-orientation is weaker than that of s-orientation. In view of this, we suggest that the a- or m-oriented Al₂O₃ is chosen as an optical window in shock-wave experiments of the high-pressure region. Our predictions could be not only helpful to understand further the optical properties of Al₂O₃ at extreme conditions, but also important for future experimental study.