The high temperature desulfurization of electrolytic manganese filter press residue was studied by direct calcination method, reduction method and calcination method with adding desulfurizer. The phase, residual sulfur content and activity of desulfurization products by different methods were studied, and the industrial applicability of several methods was compared. The results show that desulfurization slag by direct calcination method sticks seriously with crucible and it is difficult to operate in practice. The desulfurization slag by calcinations with adding coal still sticks with crucible, and contains high amount of residual sulfur. Although limestone weakens the adhesion between desulfurization slag and crucible, the activity of desulfurization slag reduces due to the formation of inert material quartz. Desulfurization slag from manganese residue with bauxite has low residual sulfur, high activity, and no adhesion to crucible. So, bauxite is a good desulfurizer for manganese residue. When the addition amount of bauxite is 42% (mass fraction), the desulfurization temperature is 1 250 ℃, and the desulfurization holding time is 5 min, the sulfur content in the desulfurization slag is 0.089 4% (mass fraction), which meets the desulfurization requirements.