• Chinese Optics Letters
  • Vol. 8, Issue 11, 1075 (2010)
Jianwei Fu, Xiaoquan Yang, Guotao Quan, and Hui Gong
Author Affiliations
  • Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China
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    DOI: 10.3788/COL20100811.1075 Cite this Article Set citation alerts
    Jianwei Fu, Xiaoquan Yang, Guotao Quan, Hui Gong. Fluorescence molecular tomography system for in vivo tumor imaging in small animals[J]. Chinese Optics Letters, 2010, 8(11): 1075 Copy Citation Text show less

    Abstract

    A fluorescence molecular tomography system for in vivo tumor imaging is developed using a 748-nm continuous wave diode laser as an excitation source. A high sensitivity cooled charge-coupled device (CCD) camera with excitation and emission filters is utilized to obtain the excitation and fluorescence images. The laser beam performs fast raster scanning using a dual-axis galvanometric scanner. The accuracy of the laser spot position at the source window is within +-200 \mum. Based on the phantom experimental results, the spatial resolution is less than 1.7 mm, and the relative quantitation error is about 10%. In vivo imaging of a tumor-bearing nude mouse tagged with near-infrared dye demonstrates the feasibility of the system.
    Jianwei Fu, Xiaoquan Yang, Guotao Quan, Hui Gong. Fluorescence molecular tomography system for in vivo tumor imaging in small animals[J]. Chinese Optics Letters, 2010, 8(11): 1075
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