A multi-point real-time nonuniformity correction method based on a System on Programmable Chip (SOPC) from Altera Company is proposed,for a large amounts of image data need to be processed in the nonuniformity correction of infrared focal plane arrays (IRFPA) and the data are difficult to correct in real-time.By creating custom instructions for the NiosⅡ embedded processor,the software algorithms are implemented by a hardware to improve the nonuniformity correction speed of the IRFPA in real time.The experimental results show that the correction speed of utilizing the SOPC hardware has increased by 150% as compared with that of utilizing the TMS320C6201 DSP hardware for the same multi-point correction.The SOPC correction implementation is characterized by its simple and flexible method and clear images,it can satisfy the requirement of real-time nonuniformity correction of IRFPA.