The plane wave expansion method is used in this paper to calculate the photonic band gap based GeSbSe and the relationship between the photonic band gap and the air holes (or media column) in photonic crystal waveguides is studied. Combining with the operating wavelength of photonic crystal waveguides, the period of 500 nm and the radius of air holes of 150 nm in a triangular lattice are determined. The twodimensional finite difference time domain method is induced to simulation the transmission characteristics both in straight and 60° bend waveguides, and the results show that the transmission efficiency in straight waveguides is much higher than those in bend waveguides. The reasons may be there are different propagation modes between straight parts and bend parts in photonic crystal waveguides. Finally, the structures of 60° bend waveguides are optimized and the results show that there is an excellent transmission efficiency in a wide range of wavelengths in photonic crystal waveguides based GeSbSe.