In view of the characteristics of high requirements for grouting material performance in large pore asphalt mixture pavement, this paper develops an early strength cement-based grouting material for semi-flexible pavement. The basic ratio of cement system was determined by mixing fast hardening sulphoaluminate cement with ordinary Portland cement in different proportions. Through the orthogonal test, the optimum ratio of mineral admixtures such as fly ash, silica fume and red mud was determined. By adding water reducing agent, rubber powder, retarder and early strength additive into the grouting material system, the working performance of grouting material was optimized and controlled, and finally, the cement-based grouting material for semi-flexible pavement meeting the performance requirements was obtained. The results show that the optimal proportion of grouting material system is m(fast hardening sulphoaluminate cement)∶m(ordinary portland cement)=7∶3, the amounts of fly ash, silica fume and red mud are 9%, 6% and 3% of the mass of sulphoaluminate-ordinary silicate composite cement, respectively, the water-binder ratio is 0.40, the sand-binder ratio is 0.25. The admixtures of early strength agent, rubber powder, water reducer and retarder are 0.08%, 2.5%, 0.35% and 0.20% (mass fraction) respectively. The initial fluidity and 20 min fluidity are 13 s and 19 s. The initial and final setting time are 62 min and 65 min, respectively, and the compressive strength is 1708 MPa, 1813 MPa, 2459 MPa and 26.19 MPa at 3 h, 1 d, 7 d and 28 d, respectively, and the drying shrinkage rate at 7 d is 0.18%.