In the simulated flight test of the missile control system, the test efficiency is low and the flight condition of missile can not be simulated.To solve the problems, a closed-loop flight simulation test scheme is proposed, which greatly satisfies the requirements for flight test of the rapidity, full coverage and effectiveness for flight test of the missile control system, and can test the coordination between the different parts of the system and the ability of the entire system to adjust to large disturbances.This paper introduces the necessity, principle and implementation method of closed-loop test, and discusses the design of the excitation signal algorithm and the method of judging missile performance based on test data.The rationality of this test scheme is verified by simulation.