Several experiments to obtain a mid-infrared 4.65 μm laser output with a Second Harmonic Generation (SHG) in AgGaSe2 crystals by a 9.3 μm pulsed TEACO2 laser were introduced. Based on the principles of nonlinear optics and laser frequency doubling, the spectral line and time shape of the pulsed TEA CO2 laser were selected and controlled,respectively, to meet the basic requirements of the pumping laser source for the wavelength and time distribution. Then taking the laser source as the fundamental wave, the research work on the SHG is performed. Experimental results show that the same AgGaSe2 crystals made by the different manufacturers displays the different surface damaged characteristics, but the bulk damaged thresholds form all the crystals are higter than their surface damaged thresholds.The experiment offers a frequency-doubled maximal single pulse energy of 12.9 mJ and an average power of 940 mW.