Our recent research on designing microstructured fiber with novel dispersion properties is reported in this paper. Two kinds of photonic crystal fibers (PCFs) are introduced first. One is the highly nonlinear PCF with broadband nearly zero flatten dispersion. With introducing the germanium-doped (Ge-doped) core into highly nonlinear PCF and optimizing the diameters of the first two inner rings of air holes, a new structure of highly nonlinear PCF was designed with the nonlinear coefficient up to 47W-1$km-1 at the wavelength 1.55 μm and nearly zero flattened dispersion of
0.5 ps/(km$nm) in telecommunication window (1460-1625 nm). Another is the highly negative PCF with a ring of fluorin-doped (Fdoped) rods to form its outer ring core while pure silica rods to form its inner core. The peak dispersion - 1064 ps/(km$nm) in 8 nm full width at half maximum (FWHM) wavelength range and - 365 ps/(km$nm) in 20 nm (FWHM) wavelength range can be reached by adjusting the structure parameters. Then, our recent research on the fabrication of PCFs is reported. Effects of draw parameters such as drawing temperature, feed speed, and furnace temperature on the geometry of the final photonic crystal fiber are investigated.