Rural restructuring is an important means of implementing and pushing forward the strategy of rural vitalization. Systematic research on the characteristics and problems of rural development and restructuring in typical areas is the basis of developing scientific policies facing the strategic needs of rural vitalization in the new era. Taking Guangxi Zhuang Autonomous Region as a case, based on the TOPSIS model supported by entropy method, this paper analyzes the spatio-temporal pattern of rural development level and restructuring intensity, identifies the problem regions of rural development and restructuring, and explores the regional path of rural vitalization. The results show that, during the research period, the level of rural development in Guangxi has been rapidly improved, and the development of rural territory is moving from relative homogeneity towards heterogeneity. The average intensity of economic, social and spatial restructuring increases gradually in each research period, and economic restructuring is accelerating, while spatial restructuring is still lagging behind. The average coupling and coordination degree of economic, social and spatial restructuring has gradually improved, but the current level of coordination is still not high. Based on the above research, 37 counties in 7 categories are identified with problems in rural development and restructuring. The formation of problem regions reflects the impact of geographical environment, and is the result of the interaction of various factors such as terrain conditions, location conditions, natural resources, economic foundation, population quality and regional policies under the background of changes in socio-economic elements. The sustainable development in rural areas depends on the economic-social-spatial coordination, and the implementation of rural vitalization strategy in Guangxi requires not only the overall planning of the regional path of rural restructuring from the macro level, but also the regulatory measures to promote rural socio-economic development and spatial restructuring for problem regions.