To solve the difficulties in laser welding cylinder, laser system, robot system and rotary machine system are controlled synchronously by means of PROFIBUS-DP field-bus, GALIL movement controller card and COMM techniques. A novel method of multifunctional control laser welding for integrated laser manufacturing systems is presented. Experiments based on this method were carried out and the results proved that the multifunctional control laser welding could meet the demands of practical applications, such as speed changing, power changing and angle deflexion. And problems of laser welding cylinder, such as welding instability and pits appeared at the end of welding, were solved. Programming is realized by VC++ object-oriented tools.