Signaling is an important part to the communication system, as well as quantum mobile communication. However, the handover strategy to quantum mobile communication signaling in adjacent cells has been researched. Quantum entanglement is the basis of the future quantum mobile communication. With the change of the position of mobile users, the entanglement degree between users and base station changes constantly. A handover strategy based on entanglement degree calculation quantum signaling in adjacent cells is proposed. Firstly, the relationship between signaling entanglement degree and distance is defined. Secondly, changes of signaling entanglement degree in adjacent cells is studied due to the change of the position of users, and a handover algorithm based on the threshold value of entanglement degree is proposed. The simulation results show that the proposed signaling handover strategy can obtain high reliability and realize smooth handover between base stations. Therefore this research will play an extremely important technical support role and standards set in constructing the signaling system quantum mobile communication network.