By using TA15 spherical powder as the raw material, the bulk specimens of TA15 titanium alloy are formed by laser deposition manufacturing. The effects of single-annealing and duplex-annealing on microstructures, tensile properties at room temperature, and anisotropy of TA15 titanium alloys are studied. The results show that, there exist significant differences in the α-phase morphologies under the two annealing methods, tensile properties at room temperature are characterized by high strength and low plasticity due to the influence of β columnar grain boundary, and the deformation in the deposition direction is relatively large. The duplex-annealing can make obvious improvements on the strength and plastic anisotropy. The micro hardness under single-annealing is hardly influenced by the increase of annealing temperature, in contrast, that under duplex-annealing increases slightly.