In order to provide a reference for clinical applications, effects of Low Intensity Laser Irradiation(LILI) withcombination of 635/808nm on cutaneous wound healings are evaluated. Non-surgical treatment of 60 patients with malignant tumors, the test group and control group of 30 cases is randomly selected. The incision site of patients has been irradiated with laser, which generated two lasers. One was red laser with wavelength at 635 ± 5nm and power density at 1~6.5 mW/cm2; the other was infrared laser with wavelength at 808 ± 5nm and power density at 11~32 mW/cm2. Laser treatment was started 24 hours after the end of surgery, each Days once every 15 minutes exposure to treatment endpoint. He-Ne laser treatment began 24 hours after the end of surgery, day 1, each exposure 15 minutes, until the end of treatment (hospital or wound healing stitches). The result shows that LILI with the combination of 635/808 nm could improve cutaneous wound healings of patients significantly rather than using He-Ne laser.