Total 60 patients who are of stage T1 and T2 transitional bladder cancer by cystoscopic examination and consequent biopsy separated are into three groups for each treatment. Photodynamic therapy (PDT) groups include group A and B which consist of 17 and 15 patients,respectively,while a controlled group has 28 patients. The PDT groups don′t have PDT until they have oral administration of CDHS801 (200 mg/50 kg) before 24 h. Then,all of them received regional irradiation using semiconductor laser at wavelength of 650 nm,with a power density of 50 J/cm2. 72 h later,transurethral resection of bladder tumor (TURBT) was performed without sunlight avoiding step for the purpose of obtaining tumor sample and further pathological analysis. The controlled group were performed routine TURBT. All the patients received intravesical chemotherapy routinely after TURBT,except for the patients in group A. The comparison criteria include of five-year survival rate,quality of life,tumor recurrence and tumor progression. The results show,patients in group A have better response of the question of quality of life than those in group B or controlled group (P<0.05). Both group A and B incidence of tumor recurrence is lower than that of the controlled group (P<0.05),but there is no significant difference of five-year survival rate and tumor progression rate among these three groups. As an assistant therapy of TURBT,photodynamic therapy may be a better alternative than intravesical chemotherapy for it is of more efficacy and safety on the treatment of T1and T2 transitional bladder caner.