1064 nm laser induced thermal injure in mice skin with different laser duration

Xun Zhou; Qiong Ma; Zhibo Liu; Hongxiang Kang

doi:10.11884/HPLPB202234.210338

Journals >High Power Laser and Particle Beams >Volume 34 >Issue 1 >Page 011012 > Article

High Power Laser and Particle Beams
Vol. 34, Issue 1, 011012 (2022)

1064 nm laser induced thermal injure in mice skin with different laser duration

Xun Zhou^1、2, Qiong Ma¹, Zhibo Liu¹, and Hongxiang Kang^1、*

Author Affiliations

¹Institute of Radiation Medicine, Academy of Military Medical Science, Academy of Military Science PLA China, Beijing100850, China

²Information and Communication Engineering College, North University of China, Taiyuan 030051, China

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DOI: 10.11884/HPLPB202234.210338 Cite this Article

Xun Zhou, Qiong Ma, Zhibo Liu, Hongxiang Kang. 1064 nm laser induced thermal injure in mice skin with different laser duration[J]. High Power Laser and Particle Beams, 2022, 34(1): 011012 Copy Citation Text

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Fig. 1. Light path diagram of 1064 nm laser radiation on living mice skin

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Dermoscope images of injure in mice skin at different duration of 1064 nm laser irradiation(a: 60 ms, b: 100 ms, c: 150 ms, d: 210 ms, e: 280 ms, f: 360 ms, g: 550 ms, h: 660 ms, i: 780 ms. Scale bar of dermoscope images: 500 μm)

Fig. 2. Dermoscope images of injure in mice skin at different duration of 1064 nm laser irradiation(a: 60 ms, b: 100 ms, c: 150 ms, d: 210 ms, e: 280 ms, f: 360 ms, g: 550 ms, h: 660 ms, i: 780 ms. Scale bar of dermoscope images: 500 μm)

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Fig. 3. Relationship between laser duration and area of damage spot

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Fig. 4. OCT images of injure in mice skin at different duration of 1064 nm laser irradiation (a: 60 ms, b: 100 ms, c: 150 ms, d: 210 ms, e: 280 ms, f: 360 ms, g: 550 ms, h: 660 ms, i: 780 ms. Scale bar of dermoscope images: 500 μm)

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Fig. 5. Relationship between laser duration and damage depth

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Fig. 6. Temperature-time fitting curve

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laser duration/ms	damage	appearance
0～100	first-degree injure	White coagulation spots appear on the skin epidermis, and the epidermis is flat
150～210	second-degree injure	Blisters appear on the skin epidermis, with raised white coagulation spots
280～550	third-degree injure	The epidermis of the skin is slightly vaporized, the dermis is degenerated, and shallow pit-like light red blood spots
660～$ \infty $	fourth-degree injure	The skin epidermis and superficial dermis are vaporized, accompanied by exudation of tissue fluid, eschars appear on the edges of the wound, and deep pit-like crimson blood spots

Table 1. Classification of 1064 nm laser induced thermal injure in biological skin tissue

laser duration/m	Ω
60	3.51×10⁻¹⁰
100	3.86×10⁻¹⁹
150	4.39
210	208.73
280	19607.46
360	4.62×10¹³
550	6.52×10¹⁴
660	2.12×10¹⁵
780	5.59×10²³

Table 2. Relationship between laser duration and degree of thermal injure

Xun Zhou, Qiong Ma, Zhibo Liu, Hongxiang Kang. 1064 nm laser induced thermal injure in mice skin with different laser duration[J]. High Power Laser and Particle Beams, 2022, 34(1): 011012

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