In the face of the increasingly complex new situation of on-orbit operation，maintenance，and fault protection of spacecraft，a method for the health status management and prediction of a power-source system is proposed，in view of the on-orbit maintenance practice of the space power-source system and the new requirements for improving the on-orbit maintenance efficiency of the power-source system.The working state of the power-source system is modeled，the varying trends of the key characteristic parameters are analyzed，and a space power-source health status prediction system is constructed.The system adopts a four-layer technical architecture including the data processing layer，the system modeling layer，the data analysis layer，and the application service layer.It has functions such as telemetry data preprocessing，system modeling，data mining analysis，and comprehensive health status evaluation，and can conduct timely，automatic，and effective monitoring and evaluation for the health status of a space power-source system.