Aiming at the fifth-generation(5G) macro-cell Mobile-to-Mobile(M2M) communication scenario that requires an efficient signal transmission model, a three-dimensional(3D) cylindrical Multiple-Input Multiple-Output(MIMO) channel is proposed. It reflects the macro-cell propagation environment in the distribution area, and the three-dimensional cylinder is the object of interference in signal transmission. The receiver(Rx) is located at the center point of the cylindrical model, and the transmitter(Tx) is located anywhere outside the scattering area. The received signal consists of the sum of Line-of-Sight(LoS) propagation components and Non-Line-of-Sight(NLoS) propagation components reflected by different objects, making the model fully adaptable to various 5G wireless communication scenarios. In addition, this paper combines the Rice fading channel, uniform distribution, Gaussian distribution, Laplace distribution, and von Mises distribution to study the statistical channel propagation characteristics, that is, the transmitter and the receiver in different directions of motion and spatial Cross-Correlation Functions(CCFs), temporal Auto-Correlation Functions(ACFs), and Doppler Power Spectral Density(PSD) of motion time. The Matlab analysis results of the transmission characteristics of the transmitter and the receiver at different time fit well with the simulation results, proving that the proposed three-dimensional model is feasible for a real 5G macrocellular mobile communication channel.