In this study, the reconstruction ability of Bessel beam propagation through biological tissue is studied via simulation and experiment. The biological tissue is modeled as a turbulent medium with slight refractive index variations. By approximating weak scattering, Bessel beam generation and propagation in biological tissue are simulated using an algorithm that combines angular spectrum theory and step-by-step propagation method. On the experimental aspect, the Bessel beam generates flexibly with a SLM, providing a tool to adjust the Bessel beam parameters and verify the simulation result. A comparison between the simulation and the experimental results is carried out. The results show that after the phase disturbance of the biological tissue, the non-diffraction length of the reconstructed beam drastically reduces, and the reconstructed beam intensity is much lower than that of the original one. The thicker the biological tissue, the lower the reconstructed beam intensity. The bright spot radius of the zeroth-order Bessel beam changes oppositely with the axicon angle, but the cone angle of the axicon has little effect on the "non-diffraction length" of the reconstructed Bessel beam after passing through the biological tissue. The lower-order Bessel beams show better reconstruction ability from the perspective of retaining the cross-section light field intensity distribution. In addition, other experimental parameters, such as the spatial beam quality of Bessel beam and positions of biological tissues, will also affect the reconstruction characteristics of Bessel beam through biological tissues. The effects of these parameters can also be studied by using the theory and method in this paper.