The bio-optical retrieval model of suspended particle concentration (Cmin) at single infrared wavelength based on the suspended particles in Tai Lake has specific mechanism. The measured data of suspended particle matter and bio-optical properties during 2006 to 2009 were used to test this bio-optical algorithm. The results indicate that the spatio-temporal variation of specific backscattering coefficient is the primary factor to the retrieval precision of suspended particles. The absorption coefficient of suspended particles in the infrared wavelength also have significant effect on the retrieval precision of suspended particles. This retrieval model can be successfully applied to the MERIS image data. The resuspended sediment will significantly increase the concentration of suspended particles in Tai lake according to the MERIS image retrieval result and wind speed monitor data in situ.