A new and low cost method for fabricating the microfluidic device was presented in this paper. The microfluidic device patterns were made from a low-melting-point electric soldering wire with 138 ℃ of melting-point and 500 μm of diameter. The patterns were dipped into a small tank containing un-solidified polydimethylsiloxane (PDMS) and solidified in a constant temperature box at 80 ℃. Then, the electric soldering wire was melted at 200 ℃ and extruded using a syringe to form the micro-channels. The microfluidic device, together with a paper-based device, was mounted on 128°-YX LiNbO3 piezoelectric substrate. A biochemical reaction on the paper-based device, in which reaction solutions were transported by the microfluidic device, can be implemented with the assistance of surface acoustic wave energy radiation. The transport of red ink solution and the color development reaction of starch were implemented by the piezoelectric microfluidic device, which verified the function of microfluidic analysis device.