Pure titanium and titanium alloys are the optimum replacement materials for the surgical implants. Laser surface modification is an attractive method to enhance the surface hardness and wear and corrosion resistance of titanium alloys. In the present study, the investigation into laser gas nitriding processing of the Ti6Al4V alloy can be used 2 kW continuous wave Nd:YAG laser under an N2 environment. With optimum process parameters, a compact laser modified coating was achieved, free of crack and porosity. The percentage composition of pernicious elements Al and V in the nitriding coating surface is very low. Morphology and composition and the frictional wear and electrochemical corrosion activities in Hank’s simulated body fluid at 37 ℃ were individually investigated by using SEM, EDX, ball-on-disc tribometer and anodic polarization measurements. The results indicated that the wear resistance and electrochemical corrosion behavior are improved significantly by laser gas nitriding without changing the property of the Ti6Al4V substrate used as biomaterial.